Toxicogenomics in Predictive Carcinogenicity

Medicine

Resistance to Targeted Therapies in Breast Cancer By Jenifer R. Prosperi
Autonomy and Human Rights in Health Care: An International Perspective by David N. Weisstub
Toxicogenomics in Predictive Carcinogenicity by Russell S Thomas, Michael D Waters, Diana Anderson
Nancy M. Trautmann, “Assessing Toxic Risk, Teacher Edition”
Adam Wittek, Grand Joldes, Poul M.F. Nielsen, Barry J. Doyle, Karol Miller – Computational Biomechanics for Medicine: From Algorithms to Models and Applications

Resistance to Targeted Therapies in Breast Cancer By Jenifer R. Prosperi

English | PDF,EPUB | 2017 | 193 Pages | ISBN : 331970141X | 4.66 MB

We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling). We have also provided an overview of standard of care as an introduction into the importance of targeted therapy. It is our hope that this volume gives an insight into the landscape of breast cancer treatment, the challenges of targeted therapy, and a glimpse into the future of breast cancer therapy.

Autonomy and Human Rights in Health Care: An International Perspective by David N. Weisstub

English | 21 Dec. 2007 | ISBN: 1402058403 | 399 Pages | PDF | 4 MB

This book offers a group of essays published in memory of David Thomasma, one of the leading humanists in the field of bioethics during the twentieth century. The authors represent many different countries and disciplines throughout the globe. The volume deals with the pressing issue of how to ground a universal bioethics in the context of the conflicted world of combative cultures and perspectives.

Toxicogenomics in Predictive Carcinogenicity by Russell S Thomas, Michael D Waters, Diana Anderson

English | 2016 | ISBN: 1782621628 | 524 Pages | PDF | 22.5 MB

Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms.
Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.
This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.

Nancy M. Trautmann, “Assessing Toxic Risk, Teacher Edition”

2001 | pages: 59 | ISBN: 0873552237 | PDF | 0,6 mb

How can we decide what concentration of arsenic is acceptable in public drinking water? What does it mean to say that Vitamin D is a highly toxic chemical? How can we balance the risks of spraying pesticides versus the risks of insect-borne diseases such as West Nile Virus, Lyme Disease, or Malaria? Students discover the answers to these intriguing questions and more by delving into the Cornell Scientific Inquiry Series: Assessing Toxic Risk, Student Edition. It includes five chapters of background text on the basic concepts of toxicology. Also included are planning forms, presentation guidelines, and peer review forms that guide students through self-designed research projects that encourage critical thinking. This integrated approach allows students to discover firsthand the natural links between biology, chemistry, environmental science, and human health.

Adam Wittek, Grand Joldes, Poul M.F. Nielsen, Barry J. Doyle, Karol Miller – Computational Biomechanics for Medicine: From Algorithms to Models and Applications

Published: 2017-05-30 | ISBN: 3319544802 | PDF | 173 pages | 6.8 MB

This volume comprises the latest developments in both fundamental science and patient-specific applications, discussing topics such as: cellular mechanics; injury biomechanics; biomechanics of heart and vascular system; medical image analysis; and both patient-specific fluid dynamics and solid mechanics simulations. With contributions from researchers world-wide, the Computational Biomechanics for Medicine series of titles provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements.

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