Gene and Cell Therapies for Beta-Globinopathies

Medicine

Prof. Grzegorz Smolka, Prof. Wojciech Wojakowski, “Transcatheter Paravalvular Leak Closure”
Introduction to Health and Safety in Construction: for the NEBOSH National Certificate in Construction Health and Safety by Phil Hughes, Ed Ferrett
Biology and Diseases of the Ferret, 3rd Edition by James G. Fox, Robert P. Marini
Gene and Cell Therapies for Beta-Globinopathies By Punam Malik
Robert F. Phalen, “Core Ethics for Health Professionals: Principles, Issues, and Compliance”

Prof. Grzegorz Smolka, Prof. Wojciech Wojakowski, “Transcatheter Paravalvular Leak Closure”

2017 | ISBN-10: 9811053995 | 187 pages | EPUB | 8 MB

Representing the first book to offer complete coverage of all related topics, this title provides up-to-date guidance on exactly why, when, and how to perform transcatheter paravalvular leak closure. An international panel of leading experts in the field address the entire spectrum of associated problems, from relevant anatomy, to imaging methods, to implantation techniques, to a comprehensive presentation of clinical data.
Specific topics covered in this book include the mechanisms of artificial valve dehiscence, with a focus on local anatomical conditions; data on conservative and surgical treatment; qualification for paravalvular leak closure; multimodality imaging techniques; a step-by-step description of access, device selection and implantation; practical tips and tricks for troubleshooting; and the latest clinical data on transcatheter paravalvular leak closure.
The book facilitates the application of contemporary knowledge in clinical cardiology, cardiac surgery, imaging and interventional cardiology in the management of patients with this challenging clinical problem.

Introduction to Health and Safety in Construction: for the NEBOSH National Certificate in Construction Health and Safety by Phil Hughes, Ed Ferrett

2015 | ISBN: 0415824362 | English | 796 pages | PDF | 53 MB

Introduction to Health and Safety in Construction has been specially written for the thousands of students who complete the NEBOSH National Certificate in Construction Health and Safety each year. Fully revised in alignment with the April 2015 syllabus, the fifth edition provides students with all they need to tackle the course with confidence.
The book covers all the essential elements of health and safety management in construction including the legal framework, risk assessment and control standards. Highly illustrated, with information provided in a clear, easily accessible format, it also provides checklists and record sheets to supplement learning.
Aligned to the NEBOSH National Certificate in Construction Health and Safety
Practice questions and answers to test knowledge and increase understanding
The only textbook endorsed for the NEBOSH National Certificate in Construction Health and Safety, the Introduction to Health and Safety in Construction is also suitable for construction courses in the UK and overseas and serves as a comprehensive reference for managers and professionals within the construction industry.

Biology and Diseases of the Ferret, 3rd Edition by James G. Fox, Robert P. Marini

2014 | ISBN: 0470960450 | English | 852 pages | EPUB | 60 MB

Biology and Diseases of the Ferret, Third Edition has been thoroughly revised and updated to provide a current, comprehensive reference on the ferret. Encyclopedic in scope, it is the only book to focus on the characteristics that make the ferret an important research animal, with detailed information on conditions, procedures, and treatments. Offering basic information on biology, husbandry, clinical medicine, and surgery, as well as unique information on the use of ferrets in biomedical research, Biology and Diseases of the Ferret is an essential resource for investigators using ferrets in the laboratory and for companion animal and comparative medicine veterinarians.
The Third Edition adds ten completely new chapters, covering regulatory considerations, black-footed ferret recovery, diseases of the cardiovascular system, viral respiratory disease research, morbillivirus research, genetic engineering, hearing and auditory function, vision and neuroplasticity research, nausea and vomiting research, and lung carcinogenesis research. Additionally, the anesthesia, surgery, and biomethodology chapter has been subdivided into three and thoroughly expanded. The book also highlights the ferret genome project, along with the emerging technology of genetically engineered ferrets, which is of particular importance to the future of the ferret as an animal model in research and will allow the investigation of diseases and their genetic basis in a small, easily maintained, non-rodent species.

Gene and Cell Therapies for Beta-Globinopathies By Punam Malik

English | PDF,EPUB | 2017 | 254 Pages | ISBN : 1493972979 | 5.02 MB

Hemoglobin defects, specifically sickle cell disease & thalassemia, combined, constitute the most common monogenic disorders in the world. In fact, nearly 2% of the world’s population carries a globin gene mutation. The transfer of the corrective globin gene through the HSC compartment by allogeneic HSC transplantation (HSCT) has already proven curative in both SCD and thalassemia patients, and provides the proof of concept that genetic manipulation of the defective organ might be equally therapeutic.
However, procedural toxicities and the requirement of an HLA-matched sibling donor limit this approach to a fraction of affected individuals. The editors review the progress & the state of the field in HSCT for hemoglobinopathies & shed light on the major changes expected in the next decade. Although allogeneic HSCT is a curative option, it is limited by the availability of matched donors, which are often available only to 15-20% of patients. An alternative to allogeneic HS
CT is genetic correction of autologous HSCs, to overcome donor availability & immune side effects. This Book reviews the progress made on additive gene therapy approaches & the current state of the field. Finally, targeted genetic correction is emerging as a novel therapeutic strategy in the hemoglobinopathies. Although ideal, the inefficiency of targeted correction was rate limiting for translation of this technology to the clinic. With advancements in zinc finger nucleases and TALE endonuclease mediated targeted correction, correction frequencies in hematopoietic stem cells is now reaching levels that may become clinically relevant. Furthermore, the ability to generate autologous embryonic stem cell like cells from primary somatic cells (skin fibroblasts or hematopoietic cells) of the affected individual has allowed for the potential application of genetic correction strategies.This Book reviews upcoming genetic strategies to reactivate fetal hemoglobin production and research advances.

Robert F. Phalen, “Core Ethics for Health Professionals: Principles, Issues, and Compliance”

English | EPUB | 2017 | 154 Pages | ISBN : 3319560883 | 1 MB

A timely overview of ethics, emphasizing applications to biomedical researchers, health providers, and administrators
There are no simple rules to guide ethical conduct in daily practice, health professionals must have a basic understanding of several topics including ethical theories; ethical scandals; laws, regulations, and institutional policies; and public perceptions. This book can be used for self-study, for classroom instruction, and as a refresher and update by practicing health professionals.
The chapters have learning objectives, focused content, a summary of important points, a quiz, and a list of key references. Although the book is arranged in a logical order, each chapter may be studied independently.